BioXcell：InVivoMAb anti-mouse CSF1R (CD115)

更新时间：2022-08-01

阅读：422

一、产品介绍
落刺激因子1受体(CSF1R)，也称为巨噬细胞集落刺激因子受体(M-CSFR)，即CD115反应。CSF1R是一种单程I型膜蛋白，是血小板衍生生长因子受体家族的成员。在小鼠中，CSF1R由单核细胞/巨噬细胞、腹膜渗出物细胞、浆细胞样和常规树突细胞以及破骨细胞表达。CSF1R是CSF1的受体，CSF1R通过CSF1R调节单核细胞谱系中细胞的增殖和分化。据报道，克隆号AFS98抗体可在体内deplete巨噬细胞并阻断CSFR1。

二、产品详情

产品详情
产品货号	BE0213
产品规格	1/5/25/50/100mg
抗体亚型	Rat IgG2a, κ
推荐同型对照	InVivoMAb rat IgG2a isotype control, anti-trinitrophenol（货号：BE0089）
推荐抗体稀释液	InVivoPure™ pH 7.0 Dilution Buffer（货号：IP0070）
免疫原	Not available or unknown
应用	in vivo macrophage depletion/in vitro CSF1R neutralization/in vivo monocyte depletion/Flow cytometry/Western blot
产品形式	PBS , pH 7.0 Contains no stabilizers or preservatives
内毒素水平	<2EU/mg (<0.002EU/μg) 使用 LAL gel clotting 测定
纯度	>95% Determined by SDS-PAGE
无菌处理	0.2 μM filtered
生产形式	从组织培养上清液中纯化得到。
纯化形式	Protein G
RRID	AB_2687699
分子量大小	150 kDa
保存条件	抗体原溶液应保存在4°C条件下，不要冷冻保存。

三、已发表文献

用途	已发表文献
in vivo macrophage depletion	Bauche, D., et al. (2018). “LAG3(+) Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis." Immunity 49(2): 342-352 e345
in vivo macrophage depletion	Gordon, S. R., et al. (2017). “PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity." Nature 545(7655): 495-499
in vivo macrophage depletion	Moynihan, K. D., et al. (2016). “Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses." Nat Med. doi: 10.1038/nm.4200
in vivo macrophage depletion	Arnold, I. C., et al. (2015). “CD11c monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23." Mucosal Immunol. doi: 10.1038/mi.2015.65
in vivo macrophage depletion	Kaminsky, L. W., et al. (2015). “Redundant Function of Plasmacytoid and Conventional Dendritic Cells Is Required To Survive a Natural Virus Infection." J Virol 89(19): 9974-9985
in vivo monocyte depletion	Naik, S., et al. (2015). “Commensal-dendritic-cell interaction specifies a unique protective skin immune signature." Nature 520(7545): 104-108
in vitro CSF-R1 neutralization	Sheng, K. C., et al. (2014). “IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages." PLoS One 9(4): e95208.
in vivo monocyte depletion	Greter, M., et al. (2012). “GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells." Immunity 36(6): 1031-1046.
in vivo macrophage depletion	Tagliani, E., et al. (2011). “Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1." J Exp Med 208(9): 1901-1916
in vivo macrophage depletion	Lim, A. K., et al. (2009). “Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice." Diabetologia 52(8): 1669-1679.

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